PROGRAM
Sunday, September 30
7:30 Continental breakfast
8:15 Welcome – Organizers
Interactions, Structure, Function 1
Session chair: Honig
8:30 Sternberg, Computational studies on the function and activity of biomolecules
9:00 Godzik, Structural Genomics meets Systems Biology – after 7 years of PSI
we know the molecular face of central metabolism in bacteria
9:30 Lichtarge, Protein
interactions: Towards rules and regulation
10:00 Coffee break
10:30 Nussinov, Modeling protein interactions: What is the
preferred way for proteins to interact?
11:00 Moult, Genetic variations in protein interfaces
11:30 Marshall, Chimeric
proteins and enzyme dynamics - the role of entropy
12:00 Lunch
Docking and Binding
Session chair: Sternberg
1:30 Abagyan, Induced fit in molecular interactions
2:00 Weng, Protein-protein docking and design with ZRANK
2:30 Ritchie/Kozakov, Practical 5D FFT docking
3:00 Coffee break
3:30 Wodak, Mechanism of 3D domain swapping in proteins
4:00 Shen/Vajda, Docking
refinement by Semidefinite Underestimation
4:30 Zhou, Toward
building structural models for multi-component protein-DNA complexes
5:00 Free time,
dinner on your own
Poster session
8:00-10:00 Poster
presentations, open bar
monday, October 1
7:30 Continental breakfast
Experimental and Computational Determination of Complexes
Session chair: Cowburn
8:30 Sali, Determining
the structures of macromolecular assemblies
9:00 Chiu, Cryo-EM based modeling of molecular machine
9:30 Aloy, Protein interaction specificity: Using 3D structures to unveil
compensatory effects in protein interaction networks
10:00 Coffee break
10:30 Cowburn, What do
experimentalists want (and what can they do)?
11:00 Joachimiak, Bridging
structural biology and genomics
11:30 Uetz, Protein-protein interactions in bacteria: from sequence to
structure
12:00 Lunch
Session chair: Sali
1:30 Chance, Merging computational and experimental data in structural mass
spectrometry experiments
2:00 Washburn, Visualizing protein complexes and protein interaction networks
with normalized spectral abundance factors
2:30 Dunbrack, Identifying biological interfaces in
protein crystal structures
3:00 Coffee break
Discussion: Protein Complex Initiative
3:30-5:30
6:30 Reception and Dinner at Liberty Hall
tuesday, October 2
7:30 Continental breakfast
Interactions, Structure, Function 2
Session chair: Merz
8:30 Gronenborn, NMR approaches to map protein-protein interactions: Methods and
applications
9:00 Honig, Using structural alignments to identify remote functional
relationships between proteins: Should the fold-based classifications of
proteins be abandoned
9:30 Skolnick, Prediction and refinement of protein complexes
10:00 Coffee break
Session chair: Skolnick
10:30 Kortemme, Design of selective and multi-specific protein interfaces
11:00 Camacho, Insights on protein disorder, foldability
and binding
11:30 Merz, Quantum Mechanics in Structural Biology
12:00 Lunch
Session chair: Uetz
1:30 Verkhivker, Protein folding and binding in signal transduction
networks: From simulations of disordered proteins to drug discovery of
cancer therapeutics
2:00 Zhang, New approaches to protein structure prediction
2:30 Coffee break
3:00 Vakser, Multiscale
approach to protein interactions
3:30 Murray, Membrane matters: Membrane mediated protein-protein interactions
4:00 Im, Understanding of helix-lipid and helix-helix interactions in
membranes
4:30 Concluding remarks – Vakser, Vajda