7:30 Continental breakfast

   8:25 Welcome - Organizers

Session chair: Sternberg

   8:35 Wodak, Intertwined association in homo-oligomeric proteins

   9:00 Bonvin, Integrative modeling of biomolecular complexes

   9:25 Vajda, Teaching new tricks to the old FFT

   9:50 Moult, 10 CASP experiments: Successes, bottlenecks, and

                            challenges in protein structure modeling

  10:15 Coffee break

Session chair: Nussinov

  10:45 Weng, Protein docking and design

  11:10 Dunbrack, TBA

  11:35 Vakser, Modeling of model-model complexes

  12:00 Lunch

Session chair: Dunbrack

   1:30 Elber, Using Molecular Dynamics to rescore predicted

                            protein complexes

   1:55 Brooks, B., Recent advances in free energy methods: NBB,

                                    Constraints, QM/MM, pH, 2D-REM

   2:20 Im, Bacterial outer membranes and interactions with

                      membrane proteins

   2:45 Coffee break

Session chair: Zhou

   3:15 Lichtarge, Evolution and disease: The calculus of life

   3:40 Grishin, Classification of protein domains focusing on

                               protein complexes

   4:05 Slusky, Charge asymmetry in proteins of the outer membrane

   4:30 Free time, dinner on your own

Poster session

   8:00 - 10:00 Poster presentations, open bar

   7:30 Continental breakfast

Session chair: Kuhlman

   8:35 Nussinov, The structural basis for signaling in cancer

                                  and inflammation

   9:00 Sternberg, Disease variants and the Interactome

   9:25 Jernigan, Computing free energies for coarse-grained

                                  structures

   9:50 Liang, Quantifying biological landscapes at multiscale:

                            Membrane proteins, chromosome folding, and

                            stochastic networks

  10:15 Coffee break

Session chair: Liang

  10:45 Olson, Modeling the biological mesoscale with

                            autoPACK/cellPACK

  11:10 Levy, Promiscuous protein interactions - a burden for the cell

                          and a tool for the biologist

  11:35 Kozakov, Faster and better docking with manifolds and

                                 encounter complexes

  12:00 Lunch

Session chair: Camacho

   1:30 Zhou, The nonrandom nature of weak interactions between

                            proteins and bystander macromolecules in cellular

                            environments

   1:55 Feig, Structural and functional implications of non-specific

                          protein interactions in cellular environments

   2:20 Kortemme, Design of protein interactions with modified

                                    and new functions

   2:45 Coffee break

Session chair: Olson

   3:15 Schueler-Furman, Putting interactions into their proper context

   3:40 Deeds, The evolution of crosstalk in signaling networks

   4:05 Ray, Structured cellular populations emerging from enzyme-

                          metabolite interactions

   4:30 DISCUSSION, Modeling the Cell

   6:30 Reception and 7:00 - 9:00 Dinner at Eldridge

   7:30 Continental breakfast

Session chair: Ma

   8:35 Aloy, Structural systems pharmacology: The role of 3D

                          structures in next generation drug development

   9:00 Brooks, C., Mapping protein-protein interfaces in search of

                              novel protein-based inhibitor leads

   9:25 Camacho, One-click drug discovery solutions among 50 million

                                  compounds for preview and download

   9:50 Karanicolas, Small-molecule inhibitors of protein-protein

                                        interactions

  10:15 Coffee break

Session chair: Brooks, C.

  10:45 Ma, Enhanced sampling and its application in structural

                        refinement

  11:10 Kuhlman, Structure-based design of bispecific antibodies

  11:35 Godzik, Cancer in 3D - understanding cancer mutations with

                              structure and network modeling

  12:00 Lunch

Session chair: Feig

   1:30 Xu, Joint evolutionary coupling analysis for residue-residue

                        contact prediction

   1:55 Elofsson, Improved contact predictions using the recognition

                                of protein like contact patterns

   2:20 Yeates, TBA

   2:45 Coffee break

Session chair: Grishin

   3:15 Bates, A flexible approach to the study of binding funnels

   3:40 Mitchell, Using orthologs to improve signal-to-noise in scoring

                                near-native docking predictions

   4:05 Kundrotas, Choosing the right one: Post-processing of initial

                                    docking models

   4:30 Concluding remarks - Vakser, Vajda